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Phenotype Image Detail
Image
Caption Healing of 25mm oblong skin wounds (A) and histology of 6mm circular skin wounds (B) in wild type and Sparctm1Hwe/Sparctm1Hwe mice. In (A) upper panel: an example of the progress of repair processes at the indicated times (days) shown. S, scab; W, open wound field. In (A) lower panel: percent of wild type and mutant mice (6 in each group) with healed wounds, defined as loss of the wound scabs and complete covering of the wounds with epidermis, is plotted versus days after excision. Panel (B) illustrates histologic appearance of 6mm wounds in a wild type and mutant mouse 4 days after surgery. Granulation (G) tissue formation is more extensive in the wild type mouse than in the mutant mouse. Arrows indicate reepithelialized wound edge. Reepithelialization appears to be as efficient in mutant mice as in wild type mice. S, scab, P, panniculus carnosus. Hematoxylin and eosin staining. Scale bar, 210um.
Copyright This image is from Basu A, BMC Cell Biol 2001;2():15, an open-access article, licensee BioMed Central Ltd. J:102567
Associated
Alleles
Symbol Name
Sparctm1Hwe secreted acidic cysteine rich glycoprotein; targeted mutation 1, Chin Chen Howe
Associated
Genotypes
Allelic Composition Genetic Background
Sparctm1Hwe/Sparctm1Hwe involves: 129S/SvEv * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory