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| Caption | Defects in vascular remodeling in Ptprbtm1Gdy/Ptprbtm1Gdy embryos. A-F: Whole-mount PECAM-1-stained E9.5 embryos. Ptprbtm1Gdy/Ptprb+ controls (A,C & E) compared with Ptprbtm1Gdy/Ptprbtm1Gdy littermates (B,D & F). C & D: A closeup of the head vasculature shows the normal remodeling pattern of veins (blue arrows) and arteries (red arrows) in control embryos (C). In mutant embryos, the venous plexus (blue arrows) undergoes only minor remodeling (D). E & F: Closeup of the cardinal vien (blue arrows), which does not form correctly in mutant embryos. (F). G & H: PECAM-1 immunostaining of E9.0 embryo cross sections at heart level. The dorsal aortas (red arrows) are small and collapsed in mutant embryos (H) compared with wild type (G), and the cardinal veins (blue arrows) are diffuse and not clearly delineated. | ||||
| Copyright | This image is from Dominguez MG, Proc Natl Acad Sci U S A 2007 Feb 27;104(9):3243-8. Copyright 2007 National Academy of Sciences, U.S.A. J:125903 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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