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| Caption | A-C: Wild type and Mrtfbtm1Eno/Mrtfbtm1Eno embryos at E10.5 (A) and E11.5 (B and C). Hematoxylin and eosin stained sections show hypoplastic sixth arch arteries in mutant embryos. Abnormal communication between the fourth and sixth arteries at E10.5 is indicated (*). Histological sections stained for SM alpha-actin show smooth muscle differentiation within the wall of branchial arch arteries and dorsal aortae in the wild type embryo. In contrast, SM alpha-actin expression is not detected in the branchial arch arteries of the mutant embryo, but expression is seen in the dorsal aorta and heart. Branchial arch arteries are numbered as 3, 4, and 6. da, dorsal aorta. D: Schematic of branchial arch arteries. The plane of section in the embryos shown in A-C is indicated by a dashed line. as, aortic sac; lda, left dorsal aorta; rda, right dorsal aorta. E: Transverse section through the heart shows incomplete ventricular septation (arrowhead) and thin myocardial wall in the mutant embryo at E13.5. lv, left ventricle; rv, right ventricle. | ||||
| Copyright | This image is from Oh J, Proc Natl Acad Sci U S A 2005 Oct 18;102(42):15122-7. Copyright 2005 National Academy of Sciences, U.S.A. J:102475 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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