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| Caption | Electron micrographs of ribbon synapses in the outer plexiform layer (OPL) from wild type (A and C) and Dnajc5tm1Sud/Dnajc5tm1Sud mice (B and D-H) at P28. Low magnification views (A and B) show dense and regular arrangement of ribbon synapses (sy) in the OPL close to the outer nuclear layer (ONL) in wild type mice (A) but not in mutant mice (B) in which degenerated ribbon synaptic complexes are found in the OPL (asterisks). The neuropil in the OPL of mutant mice was increased, with processes (fib) crossing the OPL and sprouting into the ONL (B). High magnification views (C-H) in wild type retina (C) show a typical ribbon synapse with an invaginated presynaptic terminal. In contrast, photoreceptor ribbon synapses from mutant mice displayed a pathological morphology (D-H) with decreased synaptic vesicle density (D-H) with electron-dense aggregates in some terminals (E). The arrowhead in F points to an omega-shaped exocytosis figure in a moderately degenerated ribbon terminal with three docked synaptic vesicles nearby (underlined). In the most severely degenerated presynaptic terminals (F and H), presynaptic terminals are large and electron-lucent with few synaptic vesicles but many coated vesicles (cf. F and H). ONL, outer nuclear layer; sy, ribbon synapse; n, nucleus; m, mitochondria; Inv, invagination of the postsynaptic dendrites into to the presynaptic terminal; cv, coated vesicles; fsr, floating (detached) synaptic ribbon; agg, electron dense aggregate; fib, sprouting process; pr, presynaptic; po, postsynaptic, Scale bars, A-D, 1um; E-H, 500nm. | ||||
| Copyright | This image is from Schmitz F, Proc Natl Acad Sci U S A 2006 Feb 21;103(8):2926-31. Copyright 2006 National Academy of Sciences, U.S.A. J:107310 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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