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Phenotype Image Detail
Image
Caption A and B: Low-power photomicrographs of wild type (A) and Fstl3tm1Alsc/Fstl3tm1Alsc (B) pancreas immunocytochemically stained for insulin. C and D: Hematoxylin and eosin staining of the same wild type (C) and mutant (D) tissues. Black arrowheads show numerous capillaries within the mutant islet. E and F: Immunofluorenscence photographs showing insulin (red) and glucagon (green) localization in islets from wild type (E) and mutant (F) mice. In the mutant islets, the majority of green staining is nonspecific staining of red blood cells within the islet, shown by open arrowheads. Glucagon producing alpha cells in both wild type and mutant islets are shown by solid arrowheads. Magnifications: A and B, x5; C-F, x40. Scale bars, A and B, 200um; C-F, 50um.
Copyright This image is from Mukherjee A, Proc Natl Acad Sci U S A 2007 Jan 23;104(4):1348-53. Copyright 2007 National Academy of Sciences, U.S.A. J:119526
Associated
Alleles
Symbol Name
Fstl3tm1Alsc follistatin-like 3; targeted mutation 1, Alan Schneyer
Associated
Genotypes
Allelic Composition Genetic Background
Fstl3tm1Alsc/Fstl3tm1Alsc involves: 129S4/SvJae * C57BL/6 * FVB/N

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory