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| Caption | Primary squamous cell carcinoma metastasis in Cdkn2atm1Cjs/Cdkn2atm1Cjs mice. A: Underside of skin from tumor-bearing mouse shows newly formed blood vessels surrounding tumor site (arrow) and leading to inguinal lymph node (arrowhead). B: Enlarged inguinal lymph node (left) containing metastatic squamous cell carcinoma (SCC) and blood vessel formation (arrow) compared to normal lymph node (right). C: Hematoxylin and eosin stain of carcinoma section with prominent blood vessel (bv). Carcinoma cells (ca) have penetrated blood vessel wall (arrow). D: Hematoxylin and eosin stain of lymph node bearing infiltrating SCC cells (arrow) among normal lymphocytes (arrowhead). E: Hematoxylin and eosin stain of lymph node bearing metastatic differentiated SCC. F: Immunostain with pan-keratin antibody of papilloma. G: Immunostain with pan-keratin antibody of lymph node with metastatic SCC. H and I: Hematoxylin and eosin stain of normal lung (arrowhead) with large metastatic SCC deposit (arrow). J: Hematoxylin and eosin stain of lung metastasis with secondary site of infiltration (arrow). Magnification: D-G and J, 20x; Inserts in E-G, 40x. | ||||
| Copyright | This image is from Kelly-Spratt KS, PLoS Biol 2004 Sep;2(8):E242, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:93298 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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