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| Caption | Analysis of DMBA induced tumor multiplicity and proliferative index. A: Average number of papillomas (more than 2mm in diameter) per mouse is plotted against the number of weeks post-initiation. B: Image of wild type (upper left, Arf+/+p53+/+), Cdkn2atm1Cjs/Cdkn2atm1Cjs (upper right, Arf-/-p53+/+), Trp53tm1Brd/Trp53tm1Brd (lower left, Arf+/+p53-/-) and Cdkn2atm1Cjs/Cdkn2atm1Cjs Trp53tm1Brd/Trp53tm1Brd (lower right, Arf-/-p53-/-) mice with skin tumors at time of sacrifice. Wild type mice show large exophytic tumors, while both single mutant mice have endophytic tumors. Note larger tumors in double mutant mice relative to single mutants. C: BrdU-positive cells in papillomas from wild type, single and double mutant mice at 10 weeek postinitiation. (Bars represent average counts +/- standard deviation from ten fields and five mice). Trp53tm1Brd/Trp53tm1Brd tumors show significantly fewer BrdU-positive cells than either Cdkn2atm1Cjs/Cdkn2atm1Cjs or wild type tumors (p<0.05, Wilcoxon one-sided t-test). | ||||||||
| Copyright | This image is from Kelly-Spratt KS, PLoS Biol 2004 Sep;2(8):E242, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:93298 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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