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| Caption | Gab1tm4Wbm/Gab1tm4Wbm (deltaPI3K/deltaPI3K) mice are born with open eyelids (B) compared with littermate Gab1tm4Wbm/Gab1+ control (deltaPI3K/+) (A). C-F: Coronal sections of the eyelid region of E16.5 (C and D) and E16.0 (E and F) mice. Phospho-Akt-staining is red. Scale bars: C and D, 0.25mm; E and F, 0.1mm. el, eyelid; le, lens; co, cornea. Impaired in vitro wound closure of primary mutant keratinocytes in response to Tgf-alpha is shown. After wounding, mutant (G, I and K) or heterozygous (H, J and L) keratinocytes were cultured in serum-free medium (A and B) and treated with 20 ng/ml Tgf-alpha (I and J) or with 20 units/ml HGF/SF (K and L). Pictures were taken 2 days after wounding. The dotted line indicates the position of the initial wound. | ||||
| Copyright | This image is from Schaeper U, Proc Natl Acad Sci U S A 2007 Sep 25;104(39):15376-81. Copyright 2007 National Academy of Sciences, U.S.A. J:125303 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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