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Phenotype Image Detail
Image
Caption Shown are hematoxylin and eosin stained sections (A and C) and TUNEL assay (B and D). A and B: Wild type (WT) and Vdrtm1Mbd/Vdrtm1Mbd (KO) mice fed a regular diet (Left) or a rescue diet (Right) that normalized mineral ion homeostasis. C and D: Wild type mice fed a regular diet, PhexHyp/? (Hyp) mice fed a regular diet, and wild type mice fed a high-calcium/low-phosphate diet from 18 to 24 days of age. Brackets indicate the hypertrophic chondrocyte layer. Data are representative of experiments performed on sections from three or more mice for each condition. EV, Evans blue; T, TUNEL.
Copyright This image is from Sabbagh Y, Proc Natl Acad Sci U S A 2005 Jul 5;102(27):9637-42. Copyright 2005 National Academy of Sciences, U.S.A. J:99866
Associated
Alleles
Symbol Name
PhexHyp phosphate regulating endopeptidase homolog, X-linked; hypophosphatemia
Vdrtm1Mbd vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1, Marie B Demay
Associated
Genotypes
Allelic Composition Genetic Background
Vdrtm1Mbd/Vdrtm1Mbd involves: 129S4/SvJae * C57BL/6J
PhexHyp/? involves: C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory