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| Caption | Electron micrographic analysis of Gusbmps/Gusbmps Tg(GUSB)4Sly/Tg(GUSB)4Sly (transgenic) and Gusbmps/Gusbmps (mutant) mice. Visceral epithelial cells in a glomerulus from a 3 month old mutant male mouse (A) are distended by enlarged lysosomes (arrow) containing fine fibrillar material and small fragments of membranous debris. In contrast, a 2 month old male transgenic mutant mouse (B) had no lysosomal distension in glomerular podocytes (arrow). A splenic vascular space from a newborn mutant pup (C) is lined by cells distorted by numerous expanded lysosomes. Much of the storage material was lost in processing, and only small membranous fragments (arrow) remain. A 2 month old male transgenic mutant mouse (D) had no significant vacuolar storage in vascular lining cells (arrow). Magnification: A, x3100; B, x2850; C, X2250; D, x3850. Scalebars: 5um. uranyl acetate-lead citrate. | ||||||
| Copyright | This image is from Kyle JW, Proc Natl Acad Sci U S A 1990 May;87(10):3914-8. Copyright 1990 National Academy of Sciences, U.S.A. J:21256 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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