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Phenotype Image Detail
Image
Caption All panels illustrate results from embryos at E9.5. Enzyme histochemical staining for COX activity shows no COX activity in Tfamtm1.1Lrsn/Tfamtm1.1Lrsn embryos (A) and normal COX activity in control embryos (B). Enzyme histochemical stainings for succinate dehydrogenase (SDH) were normal in mutant (C) and control (D). TUNEL staining demonstrates abundant TUNEL-positive cells (arrow) in mutant embryos (E) and a few weakly positive cells in control embryos (F). Immunohistochemical stainings to detect cleaved caspase 3 show abundant positive cells (arrow) in mutant embryos (G) and occasional positive cells in control embryos (H). Immunohistochemical stainings to detect cleaved caspase 7 are negative in mutant (I) and control (J).
Copyright This image is from Wang J, Proc Natl Acad Sci U S A 2001 Mar 27;98(7):4038-43. Copyright 2001 National Academy of Sciences, U.S.A. J:125471
Associated
Alleles
Symbol Name
Tfamtm1.1Lrsn transcription factor A, mitochondrial; targeted mutation 1.1, Nils-Goran Larsson
Associated
Genotypes
Allelic Composition Genetic Background
Tfamtm1.1Lrsn/Tfamtm1.1Lrsn involves: 129S1/Sv * 129X1/SvJ * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory