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| Caption | A: Increase in the percentage of anaphases with anaphase bridging in the GI tract of late-generation Terctm1Rdp/Terctm1Rdp (Ink4a/Arf+/+) mice. Error bars represent mean SE (n = 4-7 for each group). No significant difference between late-generation Terctm1Rdp/Terctm1Rdp (Ink4a/Arf+/+) and Cdkn2atm1Rdp/Cdkn2atm1Rdp Terctm1Rdp/Terctm1Rdp (Ink4a/Arf-/-) mice (P = 0.1306). Twenty-five anaphases were counted per sample. B: Representative examples of the degenerative phenotype seen in 12- to 13-week old G4 Terctm1Rdp/Terctm1Rdp (Ink4a/Arf+/+) and Cdkn2atm1Rdp/Cdkn2atm1Rdp Terctm1Rdp/Terctm1Rdp (Ink4a/Arf-/-) mice. C: Increase in apoptotic bodies in the crypts of the GI tract in late-generation Terctm1Rdp/Terctm1Rdp (Ink4a/Arf+/+) and Cdkn2atm1Rdp/Cdkn2atm1Rdp Terctm1Rdp/Terctm1Rdp (Ink4a/Arf-/-) mice. No significant differences between the number of apoptotic bodies between the different mutants within the same generation (P=0.9084). Error bars represent mean SE (n = 4-7 for each group). D: p53 induction in late-generation Terctm1Rdp/Terctm1Rdp (Ink4a/Arf+/+) and Cdkn2atm1Rdp/Cdkn2atm1Rdp Terctm1Rdp/Terctm1Rdp (Ink4a/Arf-/-) intestinal crypts. E: Testes weights (left) and histological sections (right) of early and late-generation Terctm1Rdp/Terctm1Rdp (Ink4a/Arf+/+) and Cdkn2atm1Rdp/Cdkn2atm1Rdp Terctm1Rdp/Terctm1Rdp (Ink4a/Arf-/-) mutant mice. Loss of Cdkn2a does not rescue germ cell depletion in late-generation Terctm1Rdp/Terctm1Rdp testes. Inset shows depletion of spermatogonia in late-generation Terctm1Rdp/Terctm1Rdp testes. | ||||||||
| Copyright | This image is from Khoo CM, Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3931-6. Copyright 2007 National Academy of Sciences, U.S.A. J:120065 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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