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| Caption | Electron micrographs of left-ventricular myocytes from wild type (A and B) and Casq2tm1Kpfe/Casq2tm1Kpfe (C-G) mouse hearts. Flat junctional sarcoplasmic reticulum (jSR) cisternae are closely apposed to T tubules (T). In wild type myocytes, cisternae are quite uniform in width and filled by calsequestrin, which is periodically arranged in small clumps ( A and B, between arrows). "Feet" (RyRs) are present in the juntional gap between the two membranes. In the mutant mouse myocytes, the jSR has variable width and is apparently empty (C-F, between arrows). (G) Longitudinal sarcoplasmic reticulum (SR) of mutant myocyte in a section that was cut tangentially to the myofibrils. The SR forms a network with large fenestrations covering the A bands and continuing across Z lines (Z). In proximity to the T tubules, the SR runs in a transverse orientation, accompanying the T tubule profiles. The SR network is quite abundant in muatnt myocytes. | ||||
| Copyright | This image is from Knollmann BC, J Clin Invest 2006 Sep;116(9):2510-20 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:114621 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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