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| Caption | A-C: Scanning electron microscopy (SEMs) of tracheal epithelial cilia from wild type (+/+) (A), Dnah5hlb612/Dnahc5+ (m/+) (B), and Dnah5hlb612/Dnah5hlb612 (m/m) (C) mice. Note the marked disorientation in the homozygous mutant cilia. Scale bar in B: 500um, A-C. D-F: Transmission electron micrographs (TEMs) show wild type cilia (D) with outer dynein arms (ODA) on almost every doublet; homozygote cilia (F) with one or no ODA; and heterozygote cilia (E), some well-populated with ODAs and others with reduced numbers of ODAs. Scale bar in E: 500nm, D-F, G-I: High-powered TEMs of wild type (G), heterozygote (H) and homosygote (I) tracheal epithelial cilia, with black arrowheads indicating ODAs. Scale bar in H: 500nm, G-I. J and K: SEMs of E7.75 wild type (J) and homozygous mutant (K) embryos show that cells in the embryonic node are monociliated. | ||||||
| Copyright | This image is from Tan SY, J Clin Invest 2007 Dec;117(12):3742-52 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:130755 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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