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Phenotype Image Detail
Image
Caption A: Alizarin red staining of Kmt2atm1Clgr/Mll1+ ( MllPTD/WT, left) and wild type (MllWT/WT, right) mice shows a rudimentary/missing thirteenth rib, indicative of a T13 to L1 transformation (penetrance of 70% in heterozygous mutant mice, n = 13). MicroCT images of the sacral spine in a (B) heterozygous mutant mouse and a (C) wild type mouse in 3D. These images are viewed from the dorsal side and illustrate the duplication of the S1 vertebral body, indicative of an S2 to S1 transformation in the heterozygous mutant mice (penetrance of 63%, n = 11).
Copyright This image is from Dorrance AM, J Clin Invest 2006 Oct;116(10):2707-16 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:115001
Associated
Alleles
Symbol Name
Kmt2atm1Clgr lysine (K)-specific methyltransferase 2A; targeted mutation 1, Michael A Caligiuri
Associated
Genotypes
Allelic Composition Genetic Background
Kmt2atm1Clgr/Kmt2a+ B6.129-Kmt2atm1Clgr

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory