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| Caption | A-H: Histological detection of iron content on cryostat sections of liver (A-D) and spleen (E-H) of wild type (WT, A,C,E and G) and Hjvtm1Arbr/Hjvtm1Arbr (Hjv-/-, B,D,F and H) mice. Note uniform iron accumulation in the liver of 2.5-month-old mutant mice and absence thereof in the red pulp of the spleen. I: Quantitative determination of iron content (umol/g dry weight) in various organs of 2.5 month old wild type (white), Hjvtm1Arbr/Hfe2+ (Hjv+/-, gray), and Hjvtm1Arbr/Hjvtm1Arbr (black) mice (n=5 for each group). Asterisks indicate significant changes (P < 0.05) in homozygous mutant mice as compared with wild type littermates. J: Time course (P12-P300) of iron content (umol/g dry weight) determined in homozygous mutant mice (squares) compared with pooled wild type and heterozygous mice (triangles). Liver (green) and spleen (blue) are depicted in the graph. At least 3 animals per time point and genotype were included in the analysis. Asterisks indicate significant changes (P<0.05) in mutant mice as compared with pooled wild type and heterozygous littermates. Scale Bar: A and B, 270um; C and D, 45um; E and F, 1.2mm; G and H, 100um. | ||||
| Copyright | This image is from Niederkofler V, J Clin Invest 2005 Aug;115(8):2180-6 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:100173 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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