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| Caption | A: Hematoxylin and eosin staining shows that in Akt1tm1Hem/Akt1tm1Hem mouse placenta, the major layers of decidua, spongiotrophoblast, and labyrinth were reduced, but the decrease of decidua was more significant that other layers. Magnification, x20. De, decidua. B, periodic acid Schiff's staining shows a marked reduction of glycogen-containing cells in the spongiotrophoblast in mutant placentae. Magnification, x20. C: Higher magnification of B, x40. Bracket indicates the glycogen-containing cells in the spongiotrophoblast. D-F: Structure of the labyrinth revealed by alkaline phosphatase staining. D, the outline of the labyrinth is clearly shown (blue color). Note that the vasculature is disordered in mutant 1. Magnification, x20. E, higher magnification of D, x40. Fetal erythrocytes are stained brown in the blood vessels. Note that in the mutant 1, fetal blood vessels were dilated, and the total blood vessel area was greatly reduced. Mutant 2 shows reduced and disordered vasculature. F, higher magnification (x100) of labyrinth. | ||||
| Copyright | This image is from Yang ZZ, J Biol Chem 2003 Aug 22;278(34):32124-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:85181 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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