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Caption | Analysis of Tsc2tm1Djk/Tsc2tm1Djk embryos. A: Immunoblot analysis demonstrating lack of tuberin expression in Tsc2tm1Djk/Tsc2tm1Djk (-/-) embryos using mAb 5E8. B: Gross anatomy of homozygous mutant embryos. C-F: Histology of mutant (C and E) and wild type (D and F) embryos. C and D: Full embryo section, identical magnification. Insets indicate area of view enlarged in E and F. E and F: Liver and adjacent organs, identical magnification. H, heart; L, liver. The mutant embryo is overall smaller, and the liver is markedly hypoplastic with dilated sinusoids (arrows) in contrast to the normal liver. Scale bars: B-D, 2mm; E and F, 200um. | ||||
Copyright | This image is from Onda H, J Clin Invest 1999 Sep;104(6):687-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:57631 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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