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| Caption | Tooth abnormalities in 1 year old Dspptm1Kul/Dspptm1Kul mice. Extracted first molars from wild type (+/+, A) and homozygous mutant (-/-, B) mice, showing enlarged pulp cavity (*) by microradiography. Similarly, decreased mineral density was observed in the incisors (arrow) of the mutant mice (D). Prominent globular mineralized zones (arrow) in mutant incisors at the incisal end are shown as insets in D. Molars of mutant mice (F-H) show discoloration (arrow) and severe attrition, leading to the complete disappearance of tooth crown (dotted circle). Frontal sections of wild type (I) and mutant (J) skulls showing the distribution of calcium staining, abnormal molar pulp cavity and resorption of the bone surrounding the teeth (*). ab, alveolar bone; to, tongue; in, incisors; m1, molar 1; m2, molar 2; m3, molar 3; mo, molars. | ||||
| Copyright | This image is from Sreenath T, J Biol Chem 2003 Jul 4;278(27):24874-80 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:84378 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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