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| Caption | Histological analysis of kidneys. A and B: Light microscopic montages of sections of wild type (Romk+/+) and Kcnj1tm1Ges/Kcnj1tm1Ges (Romk-/-) kidneys from 8 day old (top) and adult mice (bottom). Renal pelvises are grossly dilated in the mutant mice, and cortex is thinned, relatively more in the adult than in the 8 day old mouse. Scale bar, 3mm. C and D: Light microscopic images of subcortical kidney from wild type (C) and mutant (D) mice. Large lipidic inclusions (arrows) were especially numerous in the cytoplasm of the proximal tubular cells of both 7-9 day and adult mutant mice. Scale bar, 10um. E: Electron micrograph showing the lipid and myelin-like debris often found in the distal tubular lumen of adult mutant mice. Scale bar, 1um. F: Electron micrograph of mitochondria showing increased numbers of native intramitochondrial granules (arrow), a change most prominent in proximal tubular cells of adult mutant mice. Scale bar, 1um. | ||||
| Copyright | This image is from Lorenz JN, J Biol Chem 2002 Oct 4;277(40):37871-80 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:79354 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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