Phenotype Image Detail

Image

Caption

A-D: Representative photographs of wild type and Bub3^tm1Jvd/Bub3⁺ Rae1^tm1Jvd/Rae1⁺ mice at 5 (A and B) and 27 months (C and D). Note the overt cataract, severe lordokyphosis, and cachetic appearance of the 27 month old double heterozygous mouse pictured in D. E: Overall survival curves for wild type, Bub3^tm1Jvd/Bub3⁺, Rae1^tm1Jvd/Rae1⁺ and double heterozygous mice. The curve marked with an asterisk is significantly different from that of wild type mice using a log-rank test.

This image is from Baker DJ, J Cell Biol 2006 Feb 13;172(4):529-40, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:105717

Associated
Alleles

Symbol	Name
Bub3^tm1Jvd	BUB3 mitotic checkpoint protein; targeted mutation 1, Jan M A van Deursen
Rae1^tm1Jvd	ribonucleic acid export 1; targeted mutation 1, Jan M A van Deursen

Associated
Genotypes

Allelic Composition	Genetic Background
Bub3^tm1Jvd/Bub3⁺ Rae1^tm1Jvd/Rae1⁺	Not Specified

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