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Caption | A and B: Vasculature is present in wild type (Tgfb1+/+, A) yolk sac (arrows) but is not identifiable in an E12.5 Tgfb1tm1Jmu/Tgfb1tm1Jmu (Tgfb1RGE/RGE, B) embryo. C-E: Histologic appearance of wild type and mutant E12.5 yolk sacs. In the mutant yolk sacs, there is poor contact between endothelial and mesothelial layers and, in E, absence of blood cells. F: Langerhans cells (LCs) are absent in epidermis from back and ear of mutant mice. G: LCs are less abundant in back epidermis (arrows) and absent in ear epidermis of Itgb6tm1Des/Itgb6tm1Des (Itgb6-/-) mice. H: Compared with wild type mice, Itgb6tm1Des/Itgb6tm1Des mice have fewer LCs in back epidermis. P=0.001. Error bars indicate means +/-SEM. | ||||||
Copyright | This image is from Yang Z, J Cell Biol 2007 Mar 12;176(6):787-93, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:120085 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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