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| Caption | A: Wild type (+/+, left) and Chkbrmd/Chkbrmd (rmd/rmd, right) mice at 6 days of age. Note smaller size of mutant, along with deformed forelimb. B: Lateral skeletal preparation of wild type (top) and mutant (bottom) forelimbs at 6 days of age. No bones appear to be missing, although there is severe deformity of radius and ulna (arrow). C-J: Histological hematoxylin and eosin (H&E) stained sections of mutant muscle aged 66 days (C-F) and 409 days (G-J). Note areas of fatty infiltration (arrow) in hindlimb (D), not present in forelimb (C). Note centralized nuclei (arrows) in both forelimb (E) and hindlimb (F), along with degenerating fibers (arrowheads) in hindlimb along with variations in fiber size. Note severe progression of muscle wasting and extreme fatty infiltration in hindlimb (H) not present in forelimb (G). Centralized nuclei (arrows) in forlimb (I), and extensive fibrosis and degenerating fibers (arrowheads) in hindlimb (J). Scale bars: C, D, G and H, 200um; E, F, I and J, 50um; Boxes in C, D, G and H are magnified areas in E, F I and J, respectively. | ||||
| Copyright | This image is from Sher RB, J Biol Chem 2006 Feb 24;281(8):4938-48 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:108320 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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