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| Caption | Phenotypic series of adrenomedullin signaling-null mice. Genetic deletion of genes responsible for adrenomedullin (AM) signaling results in a phenotypic series of null mice with generalized edema and lethality at mid-gestation. (A) Generalized interstitial edema, without hemorrhage, was observed throughout Calcrltm1Kmca/Calcrltm1Kmca (calcrl-/-) embryos at E12.5. Similar edema was present by E13.5 in Admtm1Unc/Admtm1Unc (AM-/-) embryos (D) and by E14.5 in Ramp2tm1Kmca/Ramp2tm1Kmca (RAMP2-/-) embryos (G). Edema was not observed 1 day before onset, and no viable embryos were recovered 1-2 days after onset. Hematoxylin and eosin stained transverse sections of wild type (+/+) littermates (B,E and H) and Calcrltm1Kmca/Calcrltm1Kmca (C), Admtm1Unc/Admtm1Unc (F), and Ramp2tm1Kmca/Ramp2tm1Kmca (I) embryos at E12.5, E13.5 and E14.5, respectively. Arrowheads indicate interstitial fluid accumulation. Original magnification, A,D and G, x10; B,C,E,F,H and I, x20. | ||||||||
| Copyright | This image is from Fritz-Six KL, J Clin Invest 2008 Jan;118(1):40-50 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:130930 | ||||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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