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| Caption | A: Open arrows denote connecting cilia of cone photoreceptors for reference. Then wild type (WT) cone outer segment measures 1.3 um at its widest point and tapers distally; B, cone inner segments were sometimes observed to contain electron-dense granules (stars). C: Disorganized Gucy2etm1Gar/Gucy2etm1Gar (GC1-/-) cone outer segment reveals apparent partitioning of membrane components; lamellar structures emanate from one side of the distal connecting cilium and vesicles from the tip. D: Adjacent to the retinal pigmented epithelium (RPE), extracellular particle (2-3 um in diameter) containing vesicles and tubules surrounded by membrane lamellae appears as an end product of membrane component sorting. E: Another example of membrane partitioning is shown in which membrane layers are found to one side of the distal connecting cilium and vesicles/tubules extend from its tip. Cones were examined in a location inferior to the optic nerve for each genotype. | ||||
| Copyright | This image is from Baehr W, J Biol Chem 2007 Mar 23;282(12):8837-47 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:120903 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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