Phenotype Image Detail

Image

Caption

Electron micrographs of rod outer segments from wild type and Gucy2e^tm1Gar/Gucy2e^tm1Gar Gucy2f^tm1Wbae/Gucy2f^tm1Wbae (GCdko) mice. The open arrow indicates the connecting cilium of the wild type (WT) rod (F). Predegenerate rod outer segment (ROS) of Gucy2e^tm1Gar/Gucy2e^tm1Gar Gucy2f^tm1Wbae/Gucy2f^tm1Wbae retinas (G and H) have a striated appearance of alternating lamellae and tubules that may underline patchy patterns of rhodopsin kinase immunoreactivity.

This image is from Baehr W, J Biol Chem 2007 Mar 23;282(12):8837-47 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:120903

Associated
Alleles

Symbol	Name
Gucy2e^tm1Gar	guanylate cyclase 2e; targeted mutation 1, David L Garbers
Gucy2f^tm1Wbae	guanylate cyclase 2f; targeted mutation 1, Wolfgang Baehr

Associated
Genotypes

Allelic Composition	Genetic Background
Gucy2e^tm1Gar/Gucy2e^tm1Gar Gucy2f^tm1Wbae/Gucy2f^tm1Wbae	involves: 129S6/SvEvTac

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24