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| Caption | A: Bone marrow fibrosis in Stim1Sax/Stim1+ (Stim1Sax/+) mice. Hematoxylin and eosin (top and middle rows) and Gomori stainings (bottom row) of femural bone marrow of wild-type (WT) and heterozygous mice at different ages. Note the increased collagen deposition and bone marrow destruction in the mutant mice. B: Increased spleen size in 6 month old mutant mice. C: Effacement of the red/white pulp architecture and increased numbers of mature megakaryocytes (MK) in spleens from 6 month old mutant mice. Cryosections were stained with anti-GPIb antibodies (red) and counterstained with hematoxylin. Total cell numbers (D) and leukocyte composition (E) in spleens from 6 month old wild-type (black bars) and mutant (white bars) mice. F: A 4 day thrombopoietin (TPO) treatment caused a significant elevation of platelet counts in wild-type but not in mutant mice. d0, before treatment. n=4 per group; paired Student's t test, P<0.001. Mean +/- SD. | ||||
| Copyright | This image is from Grosse J, J Clin Invest 2007 Nov;117(11):3540-50 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:127381 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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