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Phenotype Image Detail
Image
Caption A: Gross anatomy of spleens from wild-type (+/+, top), Sh2b3tm1Paw/Sh2b3+ (+/-, middle) and Sh2b3tm1Paw/Sh2b3tm1Paw (-/-, bottom) mice. B and C: Low power magnification (10x) of hematoxylin and eosin staining of splenic sections from wild-type (B) and homozygous mutant (C) mice showing enlargement of the white (W) and red (R) pulp. D-G: Cryosections of spleens from wild-type (D and F) and mutant mice (E and G) stained with anti-B220 (red, D and E), anti-Ter119 (red, F and G), and anti-CD41 (green, F and G)-conjugated antibodies. Magnification: D and E, 50x; F and G, 200x.
Copyright This image is from Velazquez L, J Exp Med 2002 Jun 17;195(12):1599-611, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:77248
Associated
Alleles
Symbol Name
Sh2b3tm1Paw SH2B adaptor protein 3; targeted mutation 1, Tony Pawson
Associated
Genotypes
Allelic Composition Genetic Background
Sh2b3tm1Paw/Sh2b3tm1Paw either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory