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| Caption | Macroscopic and histological examination reveals phenotypic alterations of testis from Pafah1b1Gt(IRESBetageo)1Hha/Pafah1b1Gt(IRESBetageo)1Hha mice. A: Testis size is severely reduced (50% of wild-type) in Pafah1b1Gt(IRESBetageo)1Hha/Pafah1b1Gt(IRESBetageo)1Hha (panels a and b) mice. Sections through epididymis demonstrate tubules of smaller diameter that are devoid of spermatozoa in the mutant (panel c). B: Histological sections through testes from mutant mice at postnatal days 15 (a), 25 (b), 35 (c). 45 (d), and 90 (e). Control section of wild-type testis at postnatal day 90 is shown for comparison (f). Note the fairly normal appearance of germ cells in the mutant until day 45 after birth with spermatocytes and spermatids present in seminiferous tubules (a-d). However, at day 90 the tissue architecture appears grossly disturbed in the mutant, and spermatids are clustered instead of lining the luminal epithelium of the seminiferous tubules (e). In contrast to wild type testis (f), no spermatozoa are present in the mutant. | ||||
| Copyright | This image is from Nayernia K, J Biol Chem 2003 Nov 28;278(48):48377-85 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:86720 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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