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| Caption | Phenotype display of wild-type and Glcetm1Jpli/Glcetm1Jpli embryos born at 18.5 days postcoitus. A: Dissected urogenital systems of wild-type (+/+) and Glcetm1Jpli/Glcetm1Jpli (-/-) male embryos. a, adrenal gland; b, bladder; k, kidney; t, testis. Note complete absence of kidneys in the mutant embryo. B: Lungs from mutants are immature and poorly inflated, with thickened, cell-rich interalveolar septa, compared with wild-type lungs. Tissues were fixed in 10% formalin, sectioned, and stained with hematoxylin and eosin. C: Iris coloboma of mutant mice. D: Skeleton samples were stained with alcian blue-alizarin red to distinguish ossified tissue (red) from cartilage (blue). Multiple abnormalities are seen. E and F: All examined mutant embryos (n=4) lacked two proximal phalanges of the fore paws (E) and the inner phalanx of hind paws (F; arrow indicated tarsal bones). All mutant embryos showed twisted tail (G) and polydactyly on one or both forelimbs (H). | ||||
| Copyright | This image is from Li JP, J Biol Chem 2003 Aug 1;278(31):28363-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:84695 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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