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| Caption | Phenotypes of Phgdhtm1.1Shfu/Phgdhtm1.1Shfu embryos. A-D: Gross morphology of Phgdhtm1.1Shfu/Phgdhtm1.1Shfu (-/-, A) embryos and wild-type (+/+, B) littermates at 9.5 dpc and mutant embryos with Type I phenotypes (C and D) and Type II phenotypes (D) at 13.5 dpc. As early as 9.5 dpc, mutant embryos are markedly smaller than wild-type embryos. Note that the Type I embryo in D shows the beginnings of degeneration. E-G: Hematoxylin and eosin stained sagittal sections of wild-type (G) and Type I (E) and Type II (F) mutant embryos at 13.5 dpc depict abnormalities in the mutant brain. Note that the olfactory bulb (OB), ganglionic eminence (GE), and cerebellum (CB) are missing in both types of of mutant embryos. Scale bars: A and B, 500um; C and D, 2mm; E-G, 1mm. | ||||
| Copyright | This image is from Yoshida K, J Biol Chem 2004 Jan 30;279(5):3573-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:128777 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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