Phenotype Image Detail

Image

Caption

Smooth muscle coverage of aorta in embryos. A: E13.5 S1pr2^tm1Rlp/S1pr2⁺ S1pr3^tm1Rlp/S1pr3^tm1Rlp. B: S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp double null. C: S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/? embryos were sectioned transversely at the thoracic level and immunostained with anti-smooth muscle alpha-actin. S1pr2^tm1Rlp/S1pr2⁺ S1pr3^tm1Rlp/S1pr3^tm1Rlp and S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp aortae were covered normally by vascular smooth muscle cells (brackets in panels A and B). However, smooth muscle cell coverage was discontinuous around the aorta in the S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/? embryo (arrows in panel C). Scale bars, 50um.

This image is from Kono M, J Biol Chem 2004 Jul 9;279(28):29367-73 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:106055

Associated
Alleles

Symbol	Name
S1pr1^tm2Rlp	sphingosine-1-phosphate receptor 1; targeted mutation 2, Richard L Proia
S1pr2^tm1Rlp	sphingosine-1-phosphate receptor 2; targeted mutation 1, Richard L Proia
S1pr3^tm1Rlp	sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia
Tg(Tek-cre)1Ywa	transgene insertion 1, Masashi Yanagisawa

Associated
Genotypes

Allelic Composition	Genetic Background
S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/?	involves: 129S6/SvEvTac * C57BL/6 * SJL
S1pr3^tm1Rlp/S1pr3^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24