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| Caption | Embryos from Loricrintm1Der/Lor+ (+/-) intercrosses were extracted with methanol, which is thought to partially extract polar lipids, and stained with toluidine blue. Staining indicates permeability for the dye and shows immature barrier function. The approximate age of the embryos and their genotype is indicated. At E16.5 heterozygous embryos showed large unstained areas on the back skin, whereas the Loricrintm1Der/Loricrintm1Der (-/-) embryos were completely stained, indicating a delay in the formation of the skin barrier in these embryos. Wild-type (+/+) and heterozygous embryos showed a similar staining pattern (data not shown). At E17.5, mutant and wild-type (data not shown) embryos were largely unstained. | ||||
| Copyright | This image is from Koch PJ, J Cell Biol 2000 Oct 16;151(2):389-400, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65187 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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