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| Caption | Ultrastructural analysis of Snta1tm1Scf/Snta1tm1Scf neuromuscular junctions. Nerve-muscle contacts in Snta1tm1Scf/Snta1tm1Scf (a-Syn-/-, A and B) and wild-type (a-Syn+/+, D) sternomastoid muscles treated with tannic acid to highlight synaptic clefts and junctional folds (synaptic basal lamina). Folds in mutant neuromuscular juntions (NMJs) varied from near normal in appearance (straight, oriented toward the membrane; B) to moderately deranged (curved elements, short folds, folds parallel to the membrane; A). The number of junctional fold openings to the synaptic cleft was reduced in mutant NMJs. Arrows in A and B indicate the only folds that open to the cleft in the views shown. In contrast, 12 such folds are apparent in the view of the wild-type NMJs (D). Pooled data for junctional fold openings per micrometer of presynaptic membrane in wild-type and mutant NMJs are shown in C. The small vesicle-like structures (arrowhead in A), which appear to be caveoli budding from the junctional folds, were plentiful in all NMJs, although few are present in the wild-type image shown (D). Bar: A, 1.1um; B, 1.5um; D, 1.4um. | ||||
| Copyright | This image is from Adams ME, J Cell Biol 2000 Sep 18;150(6):1385-97, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:76455 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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