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Phenotype Image Detail
Image
Caption A: Comparison of wild-type (T-syn+/+) and C1galt1tm1Rpmc/C1galt1tm1Rpmc (T-syn-/-) embryos at different developmental stages. Blood is visible in the hearts of the older wild-type embryos. Arrowheads indicate hemorrhage in the brain parenchyma and ventricles, spinal cord, and spinal canal of mutant embryos. Less blood is detected in mutant hearts because of anemia. The E14 mutant embryo is dead and appears pale because blood circulation has ceased. B: Sagittal section of the E12 mutant embryo. The red and black boxes indicate hemorrhagic lesions, which are shown at higher magnification in C and D. Bleeding is visible in both the brain parenchyma and ventricles. Arrows indicate erythrocytes, which are nucleated at this stage of development.
Copyright This image is from Xia L, J Cell Biol 2004 Feb 2;164(3):451-9, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:96775
Associated
Alleles
Symbol Name
C1galt1tm1Rpmc core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1; targeted mutation 1, Roger P McEver
Associated
Genotypes
Allelic Composition Genetic Background
C1galt1tm1Rpmc/C1galt1tm1Rpmc involves: 129S1/Sv * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory