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| Caption | Phenotype of Lama3tm1Crt/Lama3tm1Crt mice. A: Newborn Lama3tm1Crt/Lama3tm1Crt (alpha3-/-) and wild-type (alpha3+/+) pups before blister formation. Arrow indicated reduced milk content in the stomach of the mutant pup. B: Progression of the phenotype in an affected pup 48 hours after birth. Blistering of the forelimbs and oral mucosa is shown. C: A 48 hour old mutant pup with severe blistering showing loss of epidermis over a significant percentage of the head and body. D: Milk in the gastrointestinal tract of the wild-type and mutant pup indicates that there is not an obstruction between the stomach and intestine (pyloric atresia) in mutant pups. The reduced stomach size and milk content was consistently observed in mutant pups. E: Front paw of a mutant pup in the early stages of blistering, ~6-8 hours after birth. The digits of the forelimbs are not detectable because epidermis has formed a cuff over the paw. F: Bleeding, indicated by the arrow, was frequently detected in the forelimbs of the mutant mice, even when blistering was not detectable. | ||||
| Copyright | This image is from Ryan MC, J Cell Biol 1999 Jun 14;145(6):1309-23, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:55865 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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