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Phenotype Image Detail
Image
Caption Whole mounts and histological analysis of E10 wild-type (A,C and E) and E9.5 Tmod1tm1Vmf/Tmod1tm1Vmf (Tmod -/-, B,D and F) embryos. Sagittal sections of wild-type (C and E) and mutant (D and F) embryos are shown. Severely underdeveloped myocardium and trabeculation (T) of the left ventricle are apparent in the mutant embryos (low and high magnification view in D and F, respectively) in comparison to wild-type (low and high magnification view in C and E, respectively). Note, in boxed in regions, complete lack of cellularization within the AV canal in mutant (F), in comparison to wild-type (E). V, ventricle; A, atrium; M, myocardium; DA, dorsal aorta; T, trabeculations; AV, AV canal; HT, heart.
Copyright This image is from Fritz-Six KL, J Cell Biol 2003 Dec 8;163(5):1033-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:87158
Associated
Alleles
Symbol Name
Tmod1tm1Vmf tropomodulin 1; targeted mutation 1, Velia M Fowler
Associated
Genotypes
Allelic Composition Genetic Background
Tmod1tm1Vmf/Tmod1tm1Vmf involves: 129S7/SvEvBrd * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory