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| Caption | A: Micro-CT 3D images of tibial metaphyses of 40 week old wild-type (+/+) and Tyrobptm1Ttk/Tyrobptm1Ttk (-/-) mice. Mutant mice showed increased bone mass. B: Hematoxylin and eosin staining of metaphysis sections from 6 week old wild-type and mutant mice. C: Percentages of trabecular bone volume per total tissue volume (BV/TV) of the femurs from wild-type (black bars) and mutant mice (white bars) at various ages. *P < 0.05. n=3. D: The numbers of TRAP+ multinucleated osteoclasts (OCs) in 6 week old wild-type and mutant mice are not significantly different. E: Transmission electron micrographs of in vivo osteoclasts from wild-type and mutant mice do not show significant differences. Mutant osteoclasts displayed a ruffled border (rb), a complex membrane structure, which is usually associated with active bone matrix resorption, and a clear zone (cz) attached to the bone matrix. | ||||
| Copyright | This image is from Kaifu T, J Clin Invest 2003 Feb;111(3):323-32 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:81823 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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