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| Caption | Morphological and histological analysis of Fkbp4tm1Shou/Fkbp4tm1Shou male mice. A: Growth curves of wild-type (WT) and Fkbp4tm1Shou/Fkbp4tm1Shou (FKBP52-/-) mice. B: Comparison of adult wild-type and mutant male external genitalia at dorsal (a and b) and ventral (c and d) surfaces. The arrows (in b and d) indicate the underdeveloped foreskin and ectopic urethral opening at the ventral aspect compared with normal morphology in wild-type (a and c). Shown are histological sections of wild-type (e) and mutant (f) male genitalia. A red arrow indicates the ectopic urethral opening at the ventral aspect compared with normal morphology in wild-type (black arrows in e). C: Three-dimensional reconstruction of the mouse embryonic day 18.5 penises. Wire frame images of outer penile skin and urethra of the three genotypes are show in a, c and e. In b, d and f, the skins had been artificially removed. The glans penis is colored in gold, whereas the urethral opening is green, corpus cavernosum (cc) is purple, and the closed urethra is blue. Note that the urethral opening persisted throughout the mutant penile shaft, whereas normal controls only have a temporary urethral opening at the distal end. The side panels show representative sections of wild-type and mutant penises. The green arrows indicate open urethra, and blue arrows indicate closed urethra. D: Comparison of anogenital distances in wild-type, heterozygous and mutant mice. The anogenital distance, normalized by the animal body weight, was significantly shorter in mutant males compared with littermate wild-type and heterozygous males. | ||||
| Copyright | This image is from Yong W, J Biol Chem 2007 Feb 16;282(7):5026-36 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:120960 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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