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| Caption | Paraffin sections of the normal (a) and Upk2tm1Tsun/Upk2tm1Tsun (b) bladders of 1 month old male mice were stained with hematoxylin and eosin. Those of normal (c) and mutant (d) bladders of 19 day old male mice were isolated 2 hours after the final i.p injection of BrdU and were stained immunohistochemically for BrdU. The inset in c shows an area with some BrdU-incorporating superficial cells. Note the increased thickness and the elevated BrdU incorporation (10.7 1.1% vs. 0.12 0.07%) of the mutant urothelium. Also note that although most of the labeling occurred in basal cells (arrows), there was occasional labeling of superficial cells (arrowheads). A total of eight mutant and eight normal mice, half of them male, were studied; 1,000-2,000 urothelial cells were examined per section from each animal; P <0.001; with no significant gender differences. Bar, 50um. | ||||
| Copyright | This image is from Kong XT, J Cell Biol 2004 Dec 20;167(6):1195-204, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:95622 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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