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Phenotype Image Detail
Image
Caption Hearts of Thbdtm2Rdr/Thbdtm2Wlr Tg(Tek-cre)1Ywa/0 mice were enlarged compared with hearts from control mice. (a) The weights of whole hearts from mutant and wild-type mice at age 3, 5 and 8 weeks, corrected for the body weight. Hearts tended to be larger at 3 weeks of age and were significanlty enlarged at 5 and 8 weeks of age in mutant mice. (b and c) H&E stained histological sections obtained at comparative levels from hearts of control (b) and mutant (c) mice. The heart of the mutant is overall enlarged with a striking hypertrophy of the right ventricular wall (arrowheads). Originial magnification, x20.
Copyright This image is from Isermann B, J Clin Invest 2001 Aug;108(4):537-46 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:71269
Associated
Alleles
Symbol Name
Tg(Tek-cre)1Ywa transgene insertion 1, Masashi Yanagisawa
Thbdtm2Rdr thrombomodulin; targeted mutation 2, Robert D Rosenberg
Thbdtm2Wlr thrombomodulin; targeted mutation 2, Harmut Weiler
Associated
Genotypes
Allelic Composition Genetic Background
Tg(Tek-cre)1Ywa/0
Thbdtm2Rdr/Thbdtm2Wlr
involves: 129S2/SvPas * C57BL/6 * SJL

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory