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| Caption | Ventricular and atrial septal defects. A: Transverse sections through the thorax of Hey2tm1Gess/Hey2tm1Gess (-/-) and Hey2+/Hey2tm1Gess (+/-) embryos at stages E12.5, E13.5, E14.5 and E16.5. While all homozygous hearts exhibit a ventricular septal defect (VSD, arrowhead), only E12.5 heterozygotes presented with a VSD that is physiological at this stage. B: An isolated VSD at stage E16.5 in a CD1 background homozygous mutant mouse similar to VSDs seen in C57BL/6 mice. C: Transverse heart sections of a homozygous mutant mouse 5 days after birth showing a VSD combined with a persistent foramen ovale (arrow, right). In control animals the foramen ovale had closed at this time point. The aorta rides over both ventricles (left). LV, RV: left, right ventricle; LA, RA, left, right atrium; IVS: interventricular septum. | ||||||
| Copyright | This image is from Fischer A, Mamm Genome 2004 Sep;15(9):711-6 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:93980 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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