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| Caption | A: The weight of Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg (-/-) P0 mice is significantly lower than that of wild-type (+/+) and heterozygous (+/-) littermates (WT, n = 8; Pds5aGt(RRM243)Byg/Pds5a+, n = 30; Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg, n =39). Error bars represent s.e.m. *P<0.001, Student's unpaired, two tailed t-test. B: Morphology of wild-type and mutant mice. Note that newborn homozygous mutant pups (right) were smaller than their wild-type littermates (left). Note too the absence of milk in the stomach of the mutant pup. Scale bar: 0.5 cm. C,D: Alizarin Red S and Alcian Blue staining of neonatal skulls demonstrates complete cleft palate (arrows) of a mutant neonate (D) compared with the proximity of palatal bones in the midline (arrow) in the wild-type control (C). Scale bar: 0.5 mm. E,F: Palatogenesis defects illustrated using H&E stained coronal sections of E18.5 wild-type (E) and mutant embryos (F). ps, palatal shelf; n, nasal bone; t, tongue. Attows in F point to the unfused palatal shelves. Scale bar: 1 mm. G-P: Alizarin Red S and Alcian Blue staining of newborn skeleton. Bone is stained red and cartilage is stained blue. G-J: Cervical and thoracic vertebrae and ribs. Note the C7-T1 fusions (arrows in H,I) and cervical rib (arrow in J) in mutant mice, compared to the normal skeletal patterning in wild-type mice (G). Cervical (C) and Thoracic (T) vertebrae are marked by numbers. K-N: Sternum morphology. Arrows denote ectopic rib-sternum conjunctions (L-N) in mutant mice compared to sternum patterning in wild-type (K). O,P: Morphology of the first cervical vertebrae. Note the unfused ossification centers at the dorsal tip of the first cervical vertebrae (arrows) in mutant mice (P) compared to wild-type (O). Scale bar for G-N: 1 mm; scale bar for O-P: 0.5 mm. Q-R: Renal abnormalities in neonatal mutant mice. Q: Bilateral renal agenesis in mutant newborn mice. AG, adrenal gland. Scale bar: 1 mm. R: Total number of glomeruli in kidneys from P0 mutant and wild-type mice were counted (n = 4 mice, 8 kidneys). | ||||
| Copyright | This image is from Zhang B, PLoS ONE 2009;4(5):e5232, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:148890 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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