Phenotype Image Detail

Image

Caption

A: A section of a wild-type mouse heart demonstrates the intact ventricular septum and its relationship to the aortic and tricuspid valves. B-D: Sections of Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg} (Pds5A^-/-) mutant hearts showing: (B) a perimembranous ventricular septal defect (VSD); (C) the pulmonary valve and artery in a heart with double outlet right ventricle; (D) the aorta arising from the right ventricle of the same heart with a muscular conus between the aortic and mitral valve (arrowhead). Arrows indicate the respective defects. Scale bar: 0.5 mm. E-J: Severe cardiac defects in Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Pds5b^tm1Jmi/Pds5b^tm1Jmi and Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg} Pds5b^tm1Jmi/Pds5b⁺ embryos. E: A section from wild-type E12.5 embryonic heart shows the separation of aorta and pulmonary artery and the developing aortic valves (arrow). F: A Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg} Pds5b^tm1Jmi/Pds5b⁺ E12.5 embryonic heart shows the underdeveloped endocardial cushion of the outflow tract and the non-septated aorta and pulmonary artery (i.e., truncus arteriosus). G: Normal association of the atrial and ventricular septae with the endocardiac cushion and valve morphogenesis in a wild-type E12.5 heart. H: A Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Pds5b^tm1Jmi/Pds5b^tm1Jmi E12.5 heart deomnstrates the dilated atria and underdeveloped endocardial cushion with no valve formation, and failure of atrioventricular canal septation. I: Wild-type E12.5 heart with a compact myocardial layer of normal thickness. J: A Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg} Pds5b^tm1Jmi/Pds5b⁺ heart has a thin compact myocardium. Doubleheaded arrows in (I,J) indicate the compact myocardial layer. Ao, aorta; PA, pulmonary artery; RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; EC, endocardial cushion; T, trabecular myocardium; C, compact myocardium.

This image is from Zhang B, PLoS ONE 2009;4(5):e5232, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:148890

Associated
Alleles

Symbol	Name
Pds5a^{Gt(RRM243)Byg}	PDS5 cohesin associated factor A; gene trap RRM243, BayGenomics
Pds5b^tm1Jmi	PDS5 cohesin associated factor B; targeted mutation 1, Jeffrey Milbrandt

Associated
Genotypes

Allelic Composition	Genetic Background
Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg}	involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Pds5b^tm1Jmi/Pds5b^tm1Jmi	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg} Pds5b^tm1Jmi/Pds5b⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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