Phenotype Image Detail

Image

Caption

Hematoxylin and eosin (H&E) stained adult ovaries (A) and testes (B) from wild-type (Syce1+/+) and Syce1^tm1Hgu/Syce1^tm1Hgu (Syce1-/-) mice. A: Mutant ovaries are greatly reduced in size and almost completely depleted of follicles in comparison to wild-type littermate with numerous follicles. B: All stages of the spematogenic cycle are apparent in the wild-type testis. Mutant testis shows a reduced diameter of the seminferous tubules and lack of postmeiotic stages. Insets, TUNEL assay for apoptotic cells. Occasional positive cells are present in the wild-type testis. In contrast, tubules with large number of positive cells were found in the mutant testis.

This image is from Bolcun-Filas E, PLoS Genet 2009 Feb;5(2):e1000393, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:146770

Associated
Alleles

Symbol	Name
Syce1^tm1Hgu	synaptonemal complex central element protein 1; targeted mutation 1, MRC Human Genetics Unit

Associated
Genotypes

Allelic Composition	Genetic Background
Syce1^tm1Hgu/Syce1^tm1Hgu	involves: 129S7/SvEvBrd * C57BL/6

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