Phenotype Image Detail

Image

Caption

Histologic analysis of tibialis anterior muscle. Cross-sections of tibialis anterior muscle from 6 week old wild-type (A-C), Myh4^tm1Lnwd/Myh4^tm1Lnwd (D-F) and Myh1^tm1Lnwd/Myh1^tm1Lnwd (G-I) mice were stained with hematoxylin and eosin (H&E, A,D and G), Masson trichrome (B,E and H) and NADH-TR (C,F and I). Note the general disarray (Myh1^tm1Lnwd/Myh1^tm1Lnwd, G), change in fiber diameter in H&E and NADH-TR stained (F and I) and the interstitial fibrosis visualized with Masson Trichrome staining (E and H).

This image is from Acakpo-Satchivi LJ, J Cell Biol 1997 Dec 1;139(5):1219-29, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported LicenseJ:44448

Associated
Alleles

Symbol	Name
Myh1^tm1Lnwd	myosin, heavy polypeptide 1, skeletal muscle, adult; targeted mutation 1, Leslie A Leinwand
Myh4^tm1Lnwd	myosin, heavy polypeptide 4, skeletal muscle; targeted mutation 1, Leslie A Leinwand

Associated
Genotypes

Allelic Composition	Genetic Background
Myh4^tm1Lnwd/Myh4^tm1Lnwd	involves: 129/Ola * 129P2/OlaHsd * C57BL/6
Myh1^tm1Lnwd/Myh1^tm1Lnwd	involves: 129/Ola * 129P2/OlaHsd * C57BL/6

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