Phenotype Image Detail

Image

Caption

Histopathological findings of ivermectin neurotoxicity in the hippocampal region from wild-type and Abcb1a^mds/Abcb1a^mds mice. Coronal sections were prepared from wild-type (n = 3) and Abcb1a^mds/Abcb1a^mds (N = 4) mice. A: Hematoxylin and eosin stained hippocampal region of wild-type mouse. B: Hematoxylin and eosin stained hippocampal region of mutant mouse. C: The close-up of CA3 layer of wild-type mouse. D: The close-up of CA3 layer of mutant mouse revealed abundance of eosinophilic cells. Arrowheads indicate the CA3 field in (A) and (B). Scale bars: (A) and (B), 200 um; (C) and (D), 80 um.

This image is from Jun K, Mamm Genome 2000 Oct;11(10):843-8 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:64725

Associated
Alleles

Symbol	Name
Abcb1a^mds	ATP-binding cassette, sub-family B member 1A; multiple drug sensitive

Associated
Genotypes

Allelic Composition	Genetic Background
Abcb1a^mds/Abcb1a^mds	involves: CF-1

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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