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Phenotype Image Detail
Image
Caption Axonal morphology in dorsal and ventral roots of old wild-type, Nefmtm1Ral/Nefmtm1Ral, Nefhtm1Ral/Nefhtm1Ral, and Nefhtm1Ral/Nefhtm1Ral Nefmtm1Ral/Nefmtm1Ral mice. Light microscopy of toluidine blue-stained cross sections of L4 dorsal (A,C,E and G) or L4 ventral (B,D,F and H) roots from 2 year old wild-type (WT, A and B) Nefmtm1Ral/Nefmtm1Ral (NF-M, C and D), Nefhtm1Ral/Nefhtm1Ral (NF-H, E and F), or Nefmtm1Ral/Nefmtm1Ral Nefhtm1Ral/Nefhtm1Ral (NF-M/H, G and H) mice. Insets show cross sections of whole roots at lower magnification. The ventral root axons in the Nefmtm1Ral/Nefmtm1Ral and double homozygous mutants appear shrunken and frequently irregular in shape. In the dorsal roots only axons in the double homozygous mutants are affected by the atrophic process. Bar, 10 um.
Copyright This image is from Elder GA, J Cell Biol 1999 Jul 12;146(1):181-92, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:77656
Associated
Alleles
Symbol Name
Nefhtm1Ral neurofilament, heavy polypeptide; targeted mutation 1, Robert A Lazzarini
Nefmtm1Ral neurofilament, medium polypeptide; targeted mutation 1, Robert A Lazzarini
Associated
Genotypes
Allelic Composition Genetic Background
Nefmtm1Ral/Nefmtm1Ral involves: 129S1/Sv * 129X1/SvJ
Nefhtm1Ral/Nefhtm1Ral involves: 129S1/Sv * 129X1/SvJ
Nefhtm1Ral/Nefhtm1Ral
Nefmtm1Ral/Nefmtm1Ral
involves: 129S1/Sv * 129X1/SvJ

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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory