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| Caption | Neuromuscular junction phenotype of Basp1tm1Crni/Basp1tm1Crni mice. B: Altered arrangement of the presynaptic nerve at the neuromuscular junction (nmj) of Basp1tm1Crni/Basp1tm1Crni (CAP23-/-) mice. Combined silver esterase stains of fast-type medial gastrocnemius nmjs (2 mo); each photograph shows one nmj (black, nerve; blue, esterase reaction product). The dotted lines mark the synaptic regions. Note the highly irregular shapes of the nerve terminal branches in the mutants, with swellings and bloblike endings. More than 90% of the nmjs exhibited obvious structural abnormalities in the mutant mice. C: Ultrastructural appearance of adult medial gastrocnemius nmjs in wild-type and mutant mice. Muscle is down and nerve is up. The nerve terminal branches are outlined in white. Arrowheads point to terminal Schwann Cell (tSC) processes. Note the hypertrophy of tSC processes, and nerve blob (left end of the photograph, white outline) surrounded by tSC processes in the photograph on the right. The photograph on the lower left shows postsynaptic junctional folds unopposed by a nerve profile (local denervation) and tSC (nucleus on the upper part of the photograph) processes insinuating into the synaptic cleft on the left. Bars: (B) 50 um; (C) 1.6 um. | ||||
| Copyright | This image is from Frey D, J Cell Biol 2000 Jun 26;149(7):1443-54, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:63023 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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