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| Caption | Wild-type (A,B) and Rab23opb/Rab23opb (C-F) fetuses at day 15 post coitum of development. Skeletal preparations of a wild-type (B) and mutant (D) fetus stained with alcian blue for cartilage and alizarin red for bone. In mutant fetuses (C,E), eyes were missing, the limbs exhibited preaxial duplications, the skin of the rostral body was detached dorsally, and spinal cords were open dorsally in lumbo-sacral (C) or thoracolumbar (E) axial regions (arrows). In the trunk region of mutant fetuses, the spinal cord defects were accompanied by neural arches which remained wide open dorsally (D, arrowheads) as compared with wild-type fetuses (B, arrowheads). Neural arches in the cervical axial region of wild-type (arrows in D) as well as mutant fetuses (arrows in B) were nearly closed. (F) Dorsal view of open aspect of the mutant spinal cord in E shown at higher magnification. Orientation of fetuses: rostral to the left. | ||||
| Copyright | This image is from Gunther T, Mamm Genome 1997 Aug;8(8):583-5 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:42171 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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